![]() ![]() ![]() In addition, this review summarizes the current understanding of the involvement of microRNAs and lncRNAs in post-transcriptional regulation and modulation of atheroma plaque and atherogenesis. ![]() This review approaches the pathophysiology of atherosclerosis from a broad perspective, examining the pathological and biochemical processes of atherosclerotic plaque formation and growth. In this study, we aimed to review the mechanism of development of atherosclerosis, including endothelial dysfunction, fatty streak formation, fibrous plaque formation, and plaque rupture. Altogether, these processes result in cardiovascular complications that remain as the leading cause of death worldwide. ![]() This process is initiated by endothelium activation, followed by a cascade of events, which implies the vessel narrowing and activation of inflammatory pathways leading to atheroma plaque formation. Atherosclerosis is a disease that is characterized by the accumulation of lipids, fibrous elements, and calcification within the large arteries. ![]()
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